Global Diseases Research

  Recent research has revealed vital information about the immune system’s response to malaria, focusing on a previously underappreciated immune cell known as TR1 cells. This discovery, published in April 2025, suggests that TR1 cells play important role in mounting an effective immune response against malaria. The findings have implications for vaccine development and the management of other challenging infections. About the Immune System The human immune system is a complex network that defends against infections. It consists of innate and adaptive immunity. Innate immunity provides immediate, non-specific defence. Adaptive immunity, on the other hand, develops a specific response and retains memory of past infections. This is crucial for effective future responses. Role of CD4+ T-Cells CD4+ T-cells are vital in the immune response. They are classified into several subsets, including helper T-cells. These cells activate B-cells and other immune components. The study focused on a ...

  The Best Researcher Award recognizes outstanding contributions to engineering through innovative research, impactful publications, and advancement of scientific knowledge. 🔗 Nominate now and celebrate the Best Researcher Award #BestResearcherAward #EngineeringExcellence #InnovativeResearch #STEMLeadership #TechInnovation #ResearchImpact #EngineerAwards #ScienceLeadership Event Details: Website: globaldiseases.org Nomination Link: https://globaldiseases.org/award-nomination/?ecategory=Awards&rcategory=Awardee To Contact: contact@globaldiseases.org

  A nine-month-old boy became the first known recipient of a custom gene-editing treatment. He suffers from CPS1 deficiency, a rare genetic disorder that leads to toxic ammonia levels in the blood. This treatment was developed by researchers at the University of Pennsylvania and the Children’s Hospital of Philadelphia, utilising an advanced technique known as base editing, a refined version of the CRISPR-Cas9 technology. About CRISPR Technology CRISPR stands for clustered regularly interspaced short palindromic repeats. It is a natural immune system found in bacteria that protects against viruses. When a virus attacks, bacteria capture a piece of the virus’s DNA and integrate it into their own genome. This allows them to remember and combat future infections. The CRISPR system uses guide RNA and the Cas9 enzyme to cut and eliminate viral DNA. The Evolution of Gene Editing The CRISPR-Cas9 tool was developed in 2012 by scientists Jennifer Doudna and Emmanuelle Charpentier. They repli...